Rapid-Acting Insulin Analogues

Rapid-Acting Insulin Analogues

Mojtaba Malek, MD

Associate Prof. of Endocrinology and Metabolism

Tehran University of Medical Sciences

Institute of Endocrinology and Metabolism

Endocrine Research Center

(Hemmat Campus)

AGENDA

• Introduction
• Pharmacokinetic Properties of Insulin
• Molecular Structure
  • Lispro
  • Glulisine
  • Aspart
• Comparison between Insulin Regular & Rapid-Acting Insulin in DM1
•  Comparison between Insulin Regular & Rapid-Acting Insulin in DM2   
• Rapid –Acting Insulin in Pregnancy
• Rapid –Acting Insulin in Elderly
•  Conclusion
• After  SQ injection regular insulin tends to dissociate from its normal hexameric form, first into dimers and then monomers.
  • Only dimeric & monomeric forms can pass through the endothelium.
• The resulting delay in the onset and duration of action, limits its effectiveness in controlling postprandial glucose.
• Dose dependent pharmacokinetics, with prolonged onset, peak, duration of action with higher doses.